Fibroblast, stained with cytopainter (red) and DAPI (blue) grown on lung tissue (green, autofluorescence). Mariam Bagher, Lungbiology, Lund University
Accumulation of the radioactive tracer 18FE-PE2I in the striatum of a rat brain. Parkinson Courtesy of Deniz Kirik
Contrast enhanced MRI in a preclinical model of arthritis. More info
Accumulation of an antibody labelled with 111In in the kidneys and a xenograft tumour of a mouse. Courtesy of Thuy Tran
Contrast enhanced MRI on mouse inner ear in vivo. More info
micro-X-ray imaging of the head of a hip-joint (caput femoralis) from a mouse. Diameter of the head is 1.3 mm. CT images: slice thickness 0.01 mm, voxel-size 0.01 x 0.01 mm. Courtesy of Gustav Grafström
9.4T magnetic resonance imaging parameter mapping in the posterior horn of ex vivo posterior horns of menisci from subjects with and without knee osteoarthritis (OA) to investigate the relationship between meniscus magnetic resonance (MR) relaxation parameters and meniscus degradation. Courtesy of Emma Olsson More info
x-ray slices of a wax model of a Auricularia Holothuria larvae Holothuria = sea cucumber Auricularia is one of the developmental stages of Marine invertebrates (the stages are auricularia, doliolaria, and pentactula). It is characterized by not feeding or reacting to food. The wax model pictured is used as a tutorial tool in biology and the model is about 12 cm long. Courtesy of Atticus Pinzon Rodriguez, Functional Zoology
Brain circuitry will change when new things are learned, and this results in changed activation patterns but can also give measurable volume changes in relevant brain regions. For example, the ease of learning to process the sounds and grammar of new languages or dialects is related to the cortical thickness in brain areas related to language processing. (M. Novén et al., Cortical thickness of Broca’s area and right homologue is related to grammar learning aptitude and pitch discrimination proficiency. Brain and Language, 2019. 188: p. 42-47)
Courtesy of Mikael novén, Mikael Roll, general linguistics
PET/CT image showing uptake of a radioactive tracer (Fluorine-18) in the spine (top) and apatite (bottom) placed in a rat abdominal muscle . The regenerative medicine group at BMC, Clinical Sciences, Lund University develops novel methods for bio-modulating biomaterials
T2-weighted imaging in an ischaemic stroke in rat to evaluate the beneficial effect of early mitogen-activated protein kinase (MEK)1/2 inhibition administered at a clinical relevant time-point using the transient middle cerebral artery occlusion model and a dedicated rodent magnetic resonance imaging system (9.4T). Courtesy of Saema Ansar
EPI fluorescence vs TIRF comparison of rat adipocyte stained for α¬-tubulin. Image courtesy of Dr Sebastian Wasserstrom, Glucose transport and protein trafficking, Lund University.
EPI fluorescence vs dSTORM comparison of rat adipocyte stained for α¬-tubulin, labeled with Alexa¬647. Image courtesy of Dr Sebastian Wasserstrom, Glucose transport and protein trafficking, Lund University.
Scanning electron microscopy image of nerve cells growing on GaP nanowire substrate. Image courtesy of Dr Maria Thereza Perez, Oftalmologi, Lund University
Non invasive quantitative flow measurements in the Circle of Willis
Ultra-high field MRI allows for high spatial and temporal resolution quantitative flow measurements in the human brain. The colors represent speed; dark blue is 0 cm/s and red is 100 cm/s. Non invasive flow and velocity measurements are used to investigate for examples blood and CSF dynamics as function of physiological states (heart rates, breathing...) and pathologies (vessel occlusion, arteriovenous malformations..). More info
In vivo 7T MRI for epilepsy studies.
High resolution images allow radiologists to find epileptic lesions that might be missed on 3T MRI images. In addition, advanced image processing methods makes it possible to make quantitative measurements, such as hippocampal subfield volumetry.
Isabella Björkman-Burtscher, Maria Compagno Strandberg, David Berron