Example inspiration
Non invasive quantitative flow measurements in the Circle of Willis
Ultra-high field MRI allows for high spatial and temporal resolution quantitative flow measurements in the human brain. The colors represent speed; dark blue is 0 cm/s and red is 100 cm/s. Non invasive flow and velocity measurements are used to investigate for examples blood and CSF dynamics as function of physiological states (heart rates, breathing...) and pathologies (vessel occlusion, arteriovenous malformations..). More info
Protection of Kidney Function with Human Antioxidation Protein α1-Microglobulin in a Mouse 177Lu-DOTATATE Radiation Therapy Model.
Peptide receptor radionuclide therapy (PRRT) is in clinical use today to treat metastatic neuroendocrine tumors. Infused, radiolabeled, somatostatin analog peptides target tumors that are killed by irradiation damage. More info
Visualization of lipid directed dynamics of perilipin 1 in human primary adipocytes.
Enrichment of cholesteryl-oleate causes segregation into topologically distinct domains in giant vesicles. More info
Composite Biomaterial as a Carrier for Bone-Active Substances for Metaphyseal Tibial Bone Defect Reconstruction in Rats
Restoring lost bone is a major challenge in orthopedic surgery. Currently available treatment strategies have shortcomings, such as risk of infection, nonunion, and excessive resorption. More info
Ultra-high field magnetic resonance imaging parameter mapping in the posterior horn of ex vivo human menisci
To investigate the relationship between meniscus magnetic resonance (MR) relaxation parameters and meniscus degradation through quantitative imaging of ex vivo posterior horns of menisci from subjects with and without knee osteoarthritis (OA). More info
Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus
By taking advantage of RFP expression, we could follow the extensive arborisation and detailed morphology of the transplanted cells. More info
Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy
MR images of infarct site as well as the evaluation of infarct volume post-administration of the vehicle control More info
MRI of autoimmune diseases
Eurostars funded EU project E!9215 - IMAID (Advanced in vivo imaging service for preclinical models to improve therapies in Autoimmune Diseases). More info
Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2
Mast cells may activate fibroblasts and contribute to remodeling processes in the lung. However, the mechanism behind these actions needs to be further investigated. Fibroblasts are major regulators of on-going remodeling processes. Protease activated receptor 2 (PAR2) expressed by fibroblasts may be activated by serine proteases, such as the mast cell mediator tryptase. More info
Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a 111In-radiolabelled monoclonal antibody, 11B6
Prostate cancer is a leading cause of death in the male population of the western world. Human kallikrein-related peptidase 2 (hK2) is abundantly expressed in malignant prostatic tissue, and its gene, KLK2, is regulated by the androgen receptor. 11B6 is a murine IgG1 monoclonal antibody directed against free human hK2. In this study, we performed a preclinical evaluation of 111In-labelled 11B6 in mouse xenografts to investigate its potential in the clinical staging and assessment of metastatic prostate cancer. More info
Mapping MRI parameters in the human knee joint using in vivo 7T MRI
Ultra-high field in vivo MRI is used to investigate methods to detect early stages of osteoarthritis (OA), including ultra-short echo time imaging and T2* mapping of cartilage and menisci. A full picture is obtained by combining in-vivo studies at 7T with investigations at LBICs preclinical platforms. More info