Type

Graduate course

Max number of participants

20

Participants/target group

Open for all interested scientists.
10 places are reserved for registered PhD students from Med Fak at LU. 

Registration deadline

2014-05-30

Admission will be notified

2014-06-15

Language

English

Course responsible

Freddy Ståhlberg, LBIC
Thuy Tran, LBIC
René in 't Zandt, LBIC
Lina Gefors, LBIC
Sven-Erik Strand, Dept. of Medical Radiation Physics

Course length

4,5 + 4,5 ECTS (4,5 ECTS obligatory for all participants + 4,5 ECTS optional as a project work)

Course date

Sept-Dec 2014

Institution

Lund University Bioimaging Center, LBIC (MedFak), Lund

Cost

Free for all PhD students

For all others:
a course fee of SEK 3 000 (4,5 ECTS) + SEK 3 000 (4,5 ECTS)

Course description

Background
Bio-imaging is a rapidly advancing field of research with a unique potential brought forward by two major non-invasive techniques: Magnetic Resonance Imaging (MRI), which comprises a variety of tools ranging from high-resolution anatomical structure visualization to functional studies and even molecular-level description of metabolic events in the cell; and Positron Emission Tomography (PET), which provide a unique means for high-sensitivity studies of physiological function and of low concentrations of molecular bio-distribution. Among other important techniques for Bioimaging on the “macroscopic” length scale are SPECT (Single Photon Emission Computed Tomography) and CT (X-ray Computed Tomography), while on the “microscopic” length scale the Electron Microscope is a research instrument with increasing importance. In addition, preclinical as well as clinical bioimaging is in a fast development phase towards the use of combined modalities in order to add value beyond what are possible using separate imaging techniques.

This graduate course aims to give PhD students, post-docs, researchers and others theoretical and practical experiences of preclinical imaging modalities mentioned above, all available at Lund University Bioimaging Center, LBIC.

Course requirements
No special requirements.

Examination
4,5 first ECTS: 80% presence on lectures representative in all modalities and 100% participation on demonstrations. Case studies in groups with oral presentation as examination.

Last 4,5 ECTS: own project from own or interested research (hands-on using LBIC instruments) or theoretical project/case: individually written and oral presentation.

Course Literature
Book: Molecular Imaging, Basic principles and Applications in Biomedical Research, 2^nd Edition, Imperial College Press, by Markus Rudin.

Sample preparation - Handbook for Transmission Electron Microscopy, Springer, by Jeanne Ayache.

Handbook of Sample Preparation for Scanning Electron Microscopy, Springer, by Patrick Echlin.

Additional hands-out will be available through course homepage/Libguide.

Information
Available on our homepage:

http://www.med.lu.se/bioimaging_center/tesla/preclin_imaging_course

Preliminary schedule

First week Sept 29 - Oct 3, 8.30 - 12.30, Dora Jacobsohn,  BMC D15

Date

Lecture

Mon Sept 29

Course introduction

Introductory about preclinical imaging, concept of molecular imaging

Hardware and Physics of MRI: introduction

Tues Sept 30

Radionuclide molecular imaging technologies: introduction

Principle of the Electron microscope

Wed Oct 1

MR spectroscopy as a tool to visualize metabolism

Preclinical PET/CT and SPECT/CT systems: technical instrumentation

Thurs Oct 2

Preparation methods for electron microscopy

Radiochemistry, imaging probes, targets, applications

Course dinner for lecturers and participants

Fri Oct 3

The use of contrast agents within MRI: clinical practice and new developments

Special preparation and combined techniques in electron microscopy

Second week Oct 6 - Oct 10, 8.30 - 12.30, Dora Jacobsohn, BMC D15

Mon Oct 6

Animal research

Data acquisition, reconstruction and quantification

Tues Oct 7

MRI of brain activation

Visualization of brain structures using diffusion weighted MRI

High resolution transmission electron microscopy (TEM)

Wed Oct 8

Radiation Safety

Human imaging at 7Tesla: challenges and new possibilities

Thurs Oct 9

EM as an diagnostic tool?

Intro to labs/demos

Go through study questions for examination

Fri Oct 10

In vivo Cerenkov/Optical imaging

Multimodality applications using nanoparticles

Preliminary schedule for Laborations/Demonstrations, 

Oct 27 - Nov 7, 8.30 - 16.30

3 persons/group 

Time

11.7T, MRS

9.4T

PET/CT

SPECT/CT

Cyklotron

Demo TEM/SEM

Sample preparation on TEM/SEM

Mon Oct 27 8.30-12.00

Group1

Group2

Group3

Group4

Group5

Group6

Grupp7

Mon Oct 27 13.00-16.30

Grupp7

Group1

Group2

Group3

Group4

Group5

Group6

Tues Oct 28 8.30-12.00

Group6

Group7

Group1

Group2

Group3

Group4

Group5

Tues Oct 28 13.00-16.30

Group5

Group6

Group7

Group1

Group2

Group3

Group4

Wed Oct 29 8.30-12.00

Group4

Group5

Group6

Group7

Group1

Group2

Group3

Wed Oct 29 13.00-16.30

Group3

Group4

Group5

Group6

Group7

Group1

Group2

Thurs Oct 30 8.30-12.00

Group2

Group3

Group4

Group5

Group6

Group7

Group1

Thurs Oct 30 13.00-16.30

Group work with examination questions

Mon-Thurs Nov 3-6

Reserved

Fri Nov 7 8.30-12.30

Examination: oral presentation in groups: study case/questions

3 pers/groups. Group list will be available on Libguide (on course intro)